![]() ![]() The difference in AhR expression between patients and controls was not affected by age, gender, or disease duration. The mean ages of the patients and controls were 33.91 ± 9.86 and 39.91 ± 14.52 years, respectively.Īs shown in Figure 1, greater AhR expression (7.03 ± 1.72) was found in the PBMCs of patients as compared to healthy controls (9.24 ± 1.99) (P = 0.000). All patients were new cases who were not being treated for their diseases or were medication-free for at least three weeks prior to the study. The clinical forms were generalized vitiligo (n=17), vitiligo universalis (n=4), and segmental vitiligo (n=1). The study group consisted of 22 patients with inactive vitiligo (11 men and 11 women) and 22 healthy controls (8 men and 14 women). cDNA amplification was conducted by qRT-PCR using SYBR Premix EX Taq II (Takara, Japan). Therefore, the purpose of this study was to examine the mRNA expression levels of Th22-specifying transcription factor AhR in vitiligo patients.Īfter blood draw and peripheral blood mononuclear cell (PBMC) separation by Ficoll-hypaque, total cellular RNA was extracted and cDNA was synthesized. 2 Such dependencies on the recruitment of specific TF can provide a valuable approach for molecular distinction of Th22 subpopulation from other important sources of IL-22 such as Th17 cells. As implied by the name, they are the most important source of IL-22, and aryl hydrocarbon receptor (AhR) is a critical transcription factor (TF) for their development. Th22 cell is a newly described subset of CD4+ T cells. Nonetheless, recent investigations indicate a marked perturbation in CD4+ T helper (Th) cells homeostasis in vitiligo patients. ![]() Unfortunately, the exact mechanism(s) that allows the immune system to recognize and kill skin melanocytes remains unknown. Many findings point toward a central role for the immune system in vitiligo pathogenesis. ![]()
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